Research Highlights

Estimation of visceral fat in 9- to 13-year-old girls using dual-energy X-ray absorptiometry (DXA) and anthropometry

Lee, V., Blew, R., Hetherington-Rauth, M., Blew, D., Galons, J. P., Hagio, T., Bea, J., Lohman, T., and Going, S. (2018). Estimation of visceral fat in 9- to 13-year-old girls using dual-energy X-ray absorptiometry (DXA) and anthropometry. Obesity science & practice, 4(5), 437-447. doi:10.1002/osp4.297

Abstract:

Objectives: Accumulation of visceral fat (VF) in children increases the risk of cardiovascular disease and type 2 diabetes, and measurement of VF in children using computed tomography and magnetic resonance imaging (MRI) is expensive. Dual-energy X-ray absorptiometry (DXA) may provide a low-cost alternative. This study aims to determine if DXA VF estimates can accurately estimate VF in young girls, determine if adding anthropometry would improve the estimate and determine if other DXA fat measures, with and without anthropometry, could be used to estimate VF in young girls.

Methods: Visceral fat was measured at lumbar intervertebral sites (L1-L2, L2-L3, L3-L4 and L4-L5) using 3.0T MRI on 32 young girls (mean age 11.3 ± 1.3 years). VF was estimated using the GE CoreScan application. Measurement of DXA android and total body fat was performed. Weight, height and waist circumference (WC) measurements were also obtained.

Results: Waist circumference and body mass index were both strongly correlated with MRI, although WC was the best anthropometric covariate. Per cent fat (%fat) variables had the strongest correlation and did best in regression models. DXA %VF (GE CoreScan) and DXA android %fat and total body %fat accounted for 65% to 74% of the variation in MRI VF.

Conclusion: Waist circumference predicted MRI VF almost as well as DXA estimates in this population, and a combination of WC and DXA fat improves the predictability of VF. DXA VF estimate was improved by the addition of WC; however, DXA android %fat with WC was better at predicting MRI VF.

KEYWORDS: Imaging; Obesity; Pediatric; Visceral fat

Read Full Article in Obesity Science and Practice

Publication Highlights

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Lee V, Blew R, Hetherington-Rauth M, Blew D, Galons JP, Hagio T, Bea J, Lohman T, Going S. Estimation of visceral fat in 9- to 13-year-old girls using dual-energy X-ray absorptiometry (DXA) and anthropometry. Obes Sci Pract. 2018 Sep 13;4(5):437-447. doi: 10.1002/osp4.297. eCollection 2018 Oct. PubMed PMID: 30338114; PubMed Central PMCID: PMC6180717.

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Grant Highlights

R25 CA 1217725 (Thomson - PI)

09/01/2017-08/31/2022

NIH/NCI

Student Transformative Experiences to Progress Underrepresented Professionals (STEP-UP)

Goal: Recruit and retain undergraduate and Master's level graduate students. Provide an integrated, innovative, multidisciplinary educational experience in cancer prevention and control research that strengthens self-efficacy and intrinsic motivation to become a cancer prevention and control scientist. Support mentoring and professional relationships with scientists, research programs and community partners.

1R01 AG055018-01 (Odegaard, PI)

06/15/2017 - 03/31/2021

NIH/NHLBI

Abdominal adipose tissue depots and cardiometabolic disease risk in postmenopausal women

Goal: New technology will derive abdominal visceral adipose tissue (VAT) values from existing DXA scans in the Women’s Health Initiative to evaluate the relationship between VAT and cardiometabolic disease risk.